Florence Sanger was the daughter of Hiram Sanger, who was of German ancestry and worked in Chicago as a bottle dealer. She lost her mother Carrie some time in the 1910s.

Interestingly, in the 1910 Census, most of the Sanger family's immediate neighbours work in the music industry - there are orchestra violinists and cellists, a church organist, a music stenographer, a piano salesman. This must have rubbed off on Florence, as by age 17 she herself was working as a stenographer for a music publisher.

Her first Columbia rolls are #599, You Said Something When You Said Dixie and #605, Wet Yo' Thumb, issued in June 1923. In total, 24 rolls are known, her last being #1014, She Loves Me, issued in December 1924.

On 10th and 14th November 1924, she accompanied famous vaudevillians the Duncan Sisters in four recordings made for the Victor company in Chicago. Vocalizing, In Sweet Onion Time, Mean Cicero Blues, and Cross-word Puzzle Blues.

Her father remarried in St. Louis in 1929, and in the 1930 Census Florence is absent from the house. Hiram died in 1933.

A record matching Florence records the death in 1984 of Florence S. Kahn, formerly Sanger, in Laguna Hills, California.